Novel bioinformatics strategies for prediction of directional sequence changes in influenza virus genomes and for surveillance of potentially hazardous strains
Identifieur interne : 000855 ( Main/Exploration ); précédent : 000854; suivant : 000856Novel bioinformatics strategies for prediction of directional sequence changes in influenza virus genomes and for surveillance of potentially hazardous strains
Auteurs : Yuki Iwasaki [Japon] ; Takashi Abe [Japon] ; Yoshiko Wada [Japon] ; Kennosuke Wada [Japon] ; Toshimichi Ikemura [Japon]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2013.
Abstract
With the remarkable increase of microbial and viral sequence data obtained from high-throughput DNA sequencers, novel tools are needed for comprehensive analysis of the big sequence data. We have developed “Batch-Learning Self-Organizing Map (BLSOM)” which can characterize very many, even millions of, genomic sequences on one plane. Influenza virus is one of zoonotic viruses and shows clear host tropism. Important issues for bioinformatics studies of influenza viruses are prediction of genomic sequence changes in the near future and surveillance of potentially hazardous strains.
To characterize sequence changes in influenza virus genomes after invasion into humans from other animal hosts, we applied BLSOMs to analyses of mono-, di-, tri-, and tetranucleotide compositions in all genome sequences of influenza A and B viruses and found clear host-dependent clustering (self-organization) of the sequences.
Viruses isolated from humans and birds differed in mononucleotide composition from each other. In addition, host-dependent oligonucleotide compositions that could not be explained with the host-dependent mononucleotide composition were revealed by oligonucleotide BLSOMs. Retrospective time-dependent directional changes of mono- and oligonucleotide compositions, which were visualized for human strains on BLSOMs, could provide predictive information about sequence changes in newly invaded viruses from other animal hosts (e.g. the swine-derived pandemic H1N1/09).
Basing on the host-dependent oligonucleotide composition, we proposed a strategy for prediction of directional changes of virus sequences and for surveillance of potentially hazardous strains when introduced into human populations from non-human sources. Millions of genomic sequences from infectious microbes and viruses have become available because of their medical and social importance, and BLSOM can characterize the big data and support efficient knowledge discovery.
Url:
DOI: 10.1186/1471-2334-13-386
PubMed: 23964903
PubMed Central: 3765179
Affiliations:
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and Technology Faculty of Engineering, Niigata University, Niigata-ken 950-2181, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Information Engineering, Institute of Science and Technology Faculty of Engineering, Niigata University, Niigata-ken 950-2181</wicri:regionArea><wicri:noRegion>Niigata-ken 950-2181</wicri:noRegion></affiliation></author><author><name sortKey="Wada, Yoshiko" sort="Wada, Yoshiko" uniqKey="Wada Y" first="Yoshiko" last="Wada">Yoshiko Wada</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama-shiShiga-ken, 526-0829, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama-shiShiga-ken, 526-0829</wicri:regionArea><wicri:noRegion>526-0829</wicri:noRegion></affiliation></author><author><name sortKey="Wada, Kennosuke" sort="Wada, Kennosuke" uniqKey="Wada K" first="Kennosuke" last="Wada">Kennosuke Wada</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama-shiShiga-ken, 526-0829, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama-shiShiga-ken, 526-0829</wicri:regionArea><wicri:noRegion>526-0829</wicri:noRegion></affiliation></author><author><name sortKey="Ikemura, Toshimichi" sort="Ikemura, Toshimichi" uniqKey="Ikemura T" first="Toshimichi" last="Ikemura">Toshimichi Ikemura</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama-shiShiga-ken, 526-0829, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama-shiShiga-ken, 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Takashi" uniqKey="Abe T" first="Takashi" last="Abe">Takashi Abe</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Information Engineering, Institute of Science and Technology Faculty of Engineering, Niigata University, Niigata-ken 950-2181, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Information Engineering, Institute of Science and Technology Faculty of Engineering, Niigata University, Niigata-ken 950-2181</wicri:regionArea><wicri:noRegion>Niigata-ken 950-2181</wicri:noRegion></affiliation></author><author><name sortKey="Wada, Yoshiko" sort="Wada, Yoshiko" uniqKey="Wada Y" first="Yoshiko" last="Wada">Yoshiko Wada</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama-shiShiga-ken, 526-0829, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama-shiShiga-ken, 526-0829</wicri:regionArea><wicri:noRegion>526-0829</wicri:noRegion></affiliation></author><author><name sortKey="Wada, Kennosuke" sort="Wada, Kennosuke" uniqKey="Wada K" first="Kennosuke" last="Wada">Kennosuke Wada</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama-shiShiga-ken, 526-0829, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama-shiShiga-ken, 526-0829</wicri:regionArea><wicri:noRegion>526-0829</wicri:noRegion></affiliation></author><author><name sortKey="Ikemura, Toshimichi" sort="Ikemura, Toshimichi" uniqKey="Ikemura T" first="Toshimichi" last="Ikemura">Toshimichi Ikemura</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama-shiShiga-ken, 526-0829, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama-shiShiga-ken, 526-0829</wicri:regionArea><wicri:noRegion>526-0829</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>With the remarkable increase of microbial and viral sequence data obtained from high-throughput DNA sequencers, novel tools are needed for comprehensive analysis of the big sequence data. We have developed “Batch-Learning Self-Organizing Map (BLSOM)” which can characterize very many, even millions of, genomic sequences on one plane. Influenza virus is one of zoonotic viruses and shows clear host tropism. Important issues for bioinformatics studies of influenza viruses are prediction of genomic sequence changes in the near future and surveillance of potentially hazardous strains.</p></sec><sec><title>Methods</title><p>To characterize sequence changes in influenza virus genomes after invasion into humans from other animal hosts, we applied BLSOMs to analyses of mono-, di-, tri-, and tetranucleotide compositions in all genome sequences of influenza A and B viruses and found clear host-dependent clustering (self-organization) of the sequences.</p></sec><sec><title>Results</title><p>Viruses isolated from humans and birds differed in mononucleotide composition from each other. In addition, host-dependent oligonucleotide compositions that could not be explained with the host-dependent mononucleotide composition were revealed by oligonucleotide BLSOMs. Retrospective time-dependent directional changes of mono- and oligonucleotide compositions, which were visualized for human strains on BLSOMs, could provide predictive information about sequence changes in newly invaded viruses from other animal hosts (e.g. the swine-derived pandemic H1N1/09).</p></sec><sec><title>Conclusions</title><p>Basing on the host-dependent oligonucleotide composition, we proposed a strategy for prediction of directional changes of virus sequences and for surveillance of potentially hazardous strains when introduced into human populations from non-human sources. Millions of genomic sequences from infectious microbes and viruses have become available because of their medical and social importance, and BLSOM can characterize the big data and support efficient knowledge discovery.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Karlin, S" uniqKey="Karlin S">S Karlin</name></author><author><name sortKey="Campbell, Am" uniqKey="Campbell A">AM Campbell</name></author><author><name sortKey="Mrazek, J" uniqKey="Mrazek J">J Mrazek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gentles, Aj" uniqKey="Gentles A">AJ Gentles</name></author><author><name sortKey="Karlin, S" uniqKey="Karlin S">S Karlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kohonen, T" uniqKey="Kohonen T">T Kohonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kohonen, T" uniqKey="Kohonen T">T Kohonen</name></author><author><name sortKey="Oja, E" uniqKey="Oja E">E Oja</name></author><author><name sortKey="Simula, O" uniqKey="Simula O">O Simula</name></author><author><name sortKey="Visa, A" uniqKey="Visa A">A Visa</name></author><author><name sortKey="Kangas, J" uniqKey="Kangas J">J Kangas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanaya, S" uniqKey="Kanaya S">S Kanaya</name></author><author><name sortKey="Kinouchi, M" uniqKey="Kinouchi M">M Kinouchi</name></author><author><name sortKey="Abe, T" uniqKey="Abe T">T Abe</name></author><author><name sortKey="Kudo, Y" uniqKey="Kudo Y">Y Kudo</name></author><author><name sortKey="Yamada, Y" uniqKey="Yamada Y">Y Yamada</name></author><author><name sortKey="Nishi, T" uniqKey="Nishi T">T Nishi</name></author><author><name sortKey="Mori, H" uniqKey="Mori H">H Mori</name></author><author><name sortKey="Ikemura, T" uniqKey="Ikemura T">T Ikemura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abe, T" uniqKey="Abe T">T Abe</name></author><author><name sortKey="Kanaya, S" uniqKey="Kanaya S">S Kanaya</name></author><author><name sortKey="Kinouchi, M" uniqKey="Kinouchi M">M Kinouchi</name></author><author><name sortKey="Ichiba, Y" uniqKey="Ichiba Y">Y Ichiba</name></author><author><name sortKey="Kozuki, T" uniqKey="Kozuki T">T Kozuki</name></author><author><name sortKey="Ikemura, T" uniqKey="Ikemura T">T Ikemura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abe, T" uniqKey="Abe T">T Abe</name></author><author><name sortKey="Sugawara, H" uniqKey="Sugawara H">H Sugawara</name></author><author><name sortKey="Kanaya, S" uniqKey="Kanaya S">S Kanaya</name></author><author><name sortKey="Ikemura, T" uniqKey="Ikemura T">T Ikemura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abe, T" uniqKey="Abe T">T Abe</name></author><author><name sortKey="Sugawara, H" uniqKey="Sugawara H">H Sugawara</name></author><author><name sortKey="Kinouchi, M" uniqKey="Kinouchi M">M Kinouchi</name></author><author><name sortKey="Kanaya, S" uniqKey="Kanaya S">S Kanaya</name></author><author><name sortKey="Ikemura, T" uniqKey="Ikemura T">T Ikemura</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Gj" uniqKey="Smith G">GJ Smith</name></author><author><name sortKey="Vijaykrishna, D" uniqKey="Vijaykrishna D">D Vijaykrishna</name></author><author><name sortKey="Bahl, J" uniqKey="Bahl J">J Bahl</name></author><author><name sortKey="Lycett, Sj" uniqKey="Lycett S">SJ Lycett</name></author><author><name sortKey="Worobey, M" uniqKey="Worobey M">M Worobey</name></author><author><name sortKey="Pybus, Og" uniqKey="Pybus O">OG Pybus</name></author><author><name sortKey="Ma, Sk" uniqKey="Ma S">SK Ma</name></author><author><name sortKey="Cheung, Cl" uniqKey="Cheung C">CL Cheung</name></author><author><name sortKey="Raghwani, J" uniqKey="Raghwani J">J Raghwani</name></author><author><name sortKey="Bhatt, S" uniqKey="Bhatt S">S Bhatt</name></author><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A Rambaut</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name></author><author><name sortKey="Davis, Ct" uniqKey="Davis C">CT Davis</name></author><author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name></author><author><name sortKey="Shu, B" uniqKey="Shu B">B Shu</name></author><author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name></author><author><name sortKey="Balish, A" uniqKey="Balish A">A Balish</name></author><author><name sortKey="Sessions, Wm" uniqKey="Sessions W">WM Sessions</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name></author><author><name sortKey="Skepner, E" uniqKey="Skepner E">E Skepner</name></author><author><name sortKey="Deyde, V" uniqKey="Deyde V">V Deyde</name></author><author><name sortKey="Okomo Adhiambo, M" uniqKey="Okomo Adhiambo M">M Okomo-Adhiambo</name></author><author><name sortKey="Gubareva, L" uniqKey="Gubareva L">L Gubareva</name></author><author><name sortKey="Barnes, J" uniqKey="Barnes J">J Barnes</name></author><author><name sortKey="Smith, Cb" uniqKey="Smith C">CB Smith</name></author><author><name sortKey="Emery, Sl" uniqKey="Emery S">SL Emery</name></author><author><name sortKey="Hillman, Mj" uniqKey="Hillman M">MJ Hillman</name></author><author><name sortKey="Rivailler, P" uniqKey="Rivailler P">P Rivailler</name></author><author><name sortKey="Smagala, J" uniqKey="Smagala J">J Smagala</name></author><author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name></author><author><name sortKey="Burke, Df" uniqKey="Burke D">DF Burke</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Pappas, C" uniqKey="Pappas C">C Pappas</name></author><author><name sortKey="Alpuche Aranda, Cm" uniqKey="Alpuche Aranda C">CM Alpuche-Aranda</name></author><author><name sortKey="L Pez Gatell, H" uniqKey="L Pez Gatell H">H López-Gatell</name></author><author><name sortKey="Olivera, H" uniqKey="Olivera H">H Olivera</name></author><author><name sortKey="L Pez, I" uniqKey="L Pez I">I López</name></author><author><name sortKey="Myers, Ca" uniqKey="Myers C">CA Myers</name></author><author><name sortKey="Faix, D" uniqKey="Faix D">D Faix</name></author><author><name sortKey="Blair, Pj" uniqKey="Blair P">PJ Blair</name></author><author><name sortKey="Yu, C" uniqKey="Yu C">C Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bush, Rm" uniqKey="Bush R">RM Bush</name></author><author><name sortKey="Bende, Ca" uniqKey="Bende C">CA Bende</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author><author><name sortKey="Fitch, Wm" uniqKey="Fitch W">WM Fitch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, Y" uniqKey="Suzuki Y">Y Suzuki</name></author><author><name sortKey="Gojobori, T" uniqKey="Gojobori T">T Gojobori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iwasaki, Y" uniqKey="Iwasaki Y">Y Iwasaki</name></author><author><name sortKey="Abe, T" uniqKey="Abe T">T Abe</name></author><author><name sortKey="Wada, K" uniqKey="Wada K">K Wada</name></author><author><name sortKey="Itoh, M" uniqKey="Itoh M">M Itoh</name></author><author><name sortKey="Ikemura, T" uniqKey="Ikemura T">T Ikemura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bao, Y" uniqKey="Bao Y">Y Bao</name></author><author><name sortKey="Bolotov, P" uniqKey="Bolotov P">P Bolotov</name></author><author><name sortKey="Dernovoy, D" uniqKey="Dernovoy D">D Dernovoy</name></author><author><name sortKey="Kiryutin, B" uniqKey="Kiryutin B">B Kiryutin</name></author><author><name sortKey="Zaslavsky, L" uniqKey="Zaslavsky L">L Zaslavsky</name></author><author><name sortKey="Tatusova, T" uniqKey="Tatusova T">T Tatusova</name></author><author><name sortKey="Ostell, J" uniqKey="Ostell J">J Ostell</name></author><author><name sortKey="Lipman, D" uniqKey="Lipman D">D Lipman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A García-Sastre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voinnet, O" uniqKey="Voinnet O">O Voinnet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alexey, A" uniqKey="Alexey A">A Alexey</name></author><author><name sortKey="Moelling, K" uniqKey="Moelling K">K Moelling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rabadan, R" uniqKey="Rabadan R">R Rabadan</name></author><author><name sortKey="Levine, Aj" uniqKey="Levine A">AJ Levine</name></author><author><name sortKey="Robins, H" uniqKey="Robins H">H Robins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenbaum, Bd" uniqKey="Greenbaum B">BD Greenbaum</name></author><author><name sortKey="Levine, Aj" uniqKey="Levine A">AJ Levine</name></author><author><name sortKey="Bhanot, G" uniqKey="Bhanot G">G Bhanot</name></author><author><name sortKey="Rabadan, R" uniqKey="Rabadan R">R Rabadan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berhane, Y" uniqKey="Berhane Y">Y Berhane</name></author><author><name sortKey="Ojkic, D" uniqKey="Ojkic D">D Ojkic</name></author><author><name sortKey="Neufeld, J" uniqKey="Neufeld J">J Neufeld</name></author><author><name sortKey="Leith, M" uniqKey="Leith M">M Leith</name></author><author><name sortKey="Hisanaga, T" uniqKey="Hisanaga T">T Hisanaga</name></author><author><name sortKey="Kehler, H" uniqKey="Kehler H">H Kehler</name></author><author><name sortKey="Ferencz, A" uniqKey="Ferencz A">A Ferencz</name></author><author><name sortKey="Wojcinski, H" uniqKey="Wojcinski H">H Wojcinski</name></author><author><name sortKey="Cottam Birt, C" uniqKey="Cottam Birt C">C Cottam-Birt</name></author><author><name sortKey="Suderman, M" uniqKey="Suderman M">M Suderman</name></author><author><name sortKey="Handel, K" uniqKey="Handel K">K Handel</name></author><author><name sortKey="Alexandersen, S" uniqKey="Alexandersen S">S Alexandersen</name></author><author><name sortKey="Pasick, J" uniqKey="Pasick J">J Pasick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, Y" uniqKey="Suzuki Y">Y Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, Y" uniqKey="Suzuki Y">Y Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ikemura, T" uniqKey="Ikemura T">T Ikemura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Domingo, E" uniqKey="Domingo E">E Domingo</name></author><author><name sortKey="Holland, Jj" uniqKey="Holland J">JJ Holland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, Mi" uniqKey="Nelson M">MI Nelson</name></author><author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abe, T" uniqKey="Abe T">T Abe</name></author><author><name sortKey="Kanaya, S" uniqKey="Kanaya S">S Kanaya</name></author><author><name sortKey="Uehara, H" uniqKey="Uehara H">H Uehara</name></author><author><name sortKey="Ikemura, T" uniqKey="Ikemura T">T Ikemura</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Iwasaki, Yuki" sort="Iwasaki, Yuki" uniqKey="Iwasaki Y" first="Yuki" last="Iwasaki">Yuki Iwasaki</name></noRegion><name sortKey="Abe, Takashi" sort="Abe, Takashi" uniqKey="Abe T" first="Takashi" last="Abe">Takashi Abe</name><name sortKey="Ikemura, Toshimichi" sort="Ikemura, Toshimichi" uniqKey="Ikemura T" first="Toshimichi" last="Ikemura">Toshimichi Ikemura</name><name sortKey="Wada, Kennosuke" sort="Wada, Kennosuke" uniqKey="Wada K" first="Kennosuke" last="Wada">Kennosuke Wada</name><name sortKey="Wada, Yoshiko" sort="Wada, Yoshiko" uniqKey="Wada Y" first="Yoshiko" last="Wada">Yoshiko Wada</name></country></tree></affiliations></record>Pour 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|texte= Novel bioinformatics strategies for prediction of directional sequence changes in influenza virus genomes and for surveillance of potentially hazardous strains
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